Slide 6 (2)

Propranolol is a medication that is quickly absorbed when taken orally. Its effects start within one to two hours after taking it. Taking it with food increases its effectiveness. The peak plasma time varies depending on whether it is immediate release or extended release. Propranolol is mostly bound to plasma proteins and is distributed throughout the body. It is metabolized in the liver and in patients with liver problems, the dosage should be adjusted. It is primarily excreted in urine. The half-life varies depending on the release form. When taken with fluoxetine, the effects of propranolol may be increased, which can cause low blood pressure, slow heart rate, and other negative effects. Routine monitoring of vital signs and EKG is recommended or consider using an alternative medication. Let's discuss the pharmacokinetics of propranolol and its interactions with fluoxetine. Propranolol is rapidly absorbed through oral administration. Onset of beta blockade effects when taken orally is approximately one to two hours. Bioavailability is increased when taken with food. Peak plasma time is approximately one to four hours in the immediate release form and six to 14 hours in the extended release form. Propranolol is mostly bound to plasma proteins and is widely distributed throughout bodily tissues. It is metabolized in the liver and in patients with hepatic impairment, dosages should be adjusted to prevent toxicity. Excretion is conducted primarily in the urine. Half-life is four to six and a half hours for immediate release and eight to 10 hours for extended release. When using propranolol and fluoxetine together, the effects of propranolol may be increased, leading to hypotension, bradycardia, AV block, and other adverse effects. The QT interval may be prolonged by EKG and therefore patients on this combination should have routine monitoring of vital signs and EKG or consider using an alternative.