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The top five biggest NBA shoe sizes in history are: 1. Shaquille O'Neal and Taco Fall, both with a size 22 shoe. 2. Brooke Lopez and Robin Lopez, both with a size 20 shoe. 3. Carl Anthony Towns also has a size 20 shoe. We got the top five biggest NBA shoe sizes in history. At number five, we have Carl Anthony Towns with a size 20. Also at number four, we have Robin Lopez with a size 20 shoe. At number three, we have Brooke Lopez as well with the same. At number two, we have Taco Fall with a size 22. Then at number one, we have Shaquille O'Neal with a size 22 as well.