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Patients with acute chest syndrome and sickle cell disease are at a higher risk of mortality and longer hospital stays. Treatment includes pain control, spirometry support, antibiotics, and transfusions to increase hemoglobin levels. Fluid management is also important to prevent pulmonary edema. Follow-up appointments are necessary for monitoring. Treatment approach for Sean's acute complication of sickle cell disease. Acute chest syndrome and sickle cell disease patients have a higher risk of mortality and prolonged hospitalization. Therefore, the following treatments are recommended. Acute intervention such as pain control through medications such as NSAIDs and or opioids. Spirometry support including supplemental oxygen to maintain oxygen saturation above 94%, incentive spirometry to prevent apoplexis, bronchodilators to aid in wheezing, broad spectrum antibiotics are prescribed, simple or exchange transfusion to increase the hemoglobin concentration to 9 to 11 grams per liter. Fluid management to correct dehydration by maintaining fluids in a three-fourths to one ratio to avoid pulmonary edema and routine follow-up appointments.