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In the NBA, the top five highest-scoring games are as follows: Wilt Chamberlain scored 72, 73 (tied with David Thompson), and 78 points. Kobe Bryant scored 81 points, and Wilt Chamberlain holds the record with 100 points in a single game. We got the top five most points scored in an NBA game. Let's get right into it. Starting off at number five, we have Wilt Chamberlain with 72 points. Then tied for the number four spot is Wilt Chamberlain and David Thompson with 73 points in an NBA game. Then at number three, we have Wilt Chamberlain as well with 78. Then at number two, we have Kobe Bryant with 81. And at number one, obviously we have the 100 point game by Wilt Chamberlain.