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Can computer simulations replace human trials? This episode explores a rigorous framework for in silico clinical trials that establishes credibility through verification, validation, and uncertainty quantification. This method uses a build-validate-predict structure to address uncertainties. Our neuromodulation device case study demonstrates how validated models could transform medical device testing—reducing costs and ethical concerns while maintaining scientific integrity.
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Can computer simulations replace human trials? This episode explores a rigorous framework for in silico clinical trials that establishes credibility through verification, validation, and uncertainty quantification. This method uses a build-validate-predict structure to address uncertainties. Our neuromodulation device case study demonstrates how validated models could transform medical device testing—reducing costs and ethical concerns while maintaining scientific integrity.
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